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Company Profile

Cambridge Major Laboratories, Inc. is a leading global service-based chemistry outsourcing partner to the pharmaceutical and biotechnology industries, producing pharmaceutical intermediates, Active Pharmaceutical Ingredients, and other fine organic chemicals. The Company specializes in chemical process development and advanced multi-step organic synthesis, and operates out of three facilities in the US and Europe. The Company has been FDA inspected and approved for cGMP manufacturing. Visit us at http://www.c-mlabs.com/.

At Cambridge Major, we provide a full range of chemistry services ranging from new route development (where no synthetic procedures exist), to production using customer-supplied synthesis protocols. Based on our expertise in a wide range of chemistries, we can accommodate most small-molecule custom synthesis programs. Our equipment allows us to handle projects ranging from -70C to 130C, and pressures up to 300 psi. We routinely handle alkyl lithium, azides, phosgene and other difficult-to-handle reagents. Our chemistries are shown below:

Palladium and Nickel Catalyzed Reactions

• Heck

• Sonogashira

• Suzuki and Related 

 

Organometallic Chemistry

• Grignard

• Alkyllilthiums 

 

Heterocycles

• Pyridines

• Quinolones

• Thiophenes

• Oxazoles

• Piperazines

• Phenazines

• Indoles and Tryptophanes

     - Ring Synthesis: Fischer, Batcho-Leimgruber, Muchowski,

       Reissert, Japp-Klingemann, Moody, Madelung

     - Ring Modification and Substitution

• Furanes

     - Cu-Catalyzed Arylation

     - Side-Chain Modification

     - Aminoalkylation.

 

 Biphenyls and Fluorenes

• Synthesis: DMG-Snieckus and Suzuki

• Cyclizations: PPA, Friedel-Crafts and Eaton's

• Side-Chain Modification and Substitution 

 

Amino Acids and Small Peptides

• Protection of Amino and Carboxylic Group

• Functional Modifications: Formation of Alcohols, Aldehydes,

   Aminoketones, Carbonylimidazolides, Mixed Anhydrides, etc...

• Direct and Assisted by Auxiliary Reagents Peptide Bond Formation 

 

Nucleosides and Sugars

• Synthesis and Modification of Nucleobase

• Protection, Modification and Deoxygenation of Ribose Ring

• Coupling and Deprotection 

 

Reagents for Nucleotide Synthesis

• Phos Reagent

• Menpoc Chloride

 

Classical Organic Synthesis

• Acetoacylation, Acylation, Aldol Condensation, Alkoxylation,

  Alkylation, Allylic Bromination, Amidation, Amination

• Benzoylation, Bromination

• Carbamoylation, Carboxylation, Chlorination, Chloromethylation,

  Chlorosulfonation, Claisen Condensation, Cyclopropanations, Cyanation, Cyclization

• Dealkylation, Decarboxylation, Dehalogenation, Dehydrogenation, Deoxygenation,

  Diazotization, Dieckmann Cyclization, Diels-Alder, Doebner-Knoevenagel   Condensation

• Esterification, Etherification

• Formylation, Friedel-Crafts, Fries Rearrangement

• Gomberg-Bachmann, Grignard

• Halide Exchange, Halogenation, Hofman Degradation,

  Hydroformylation, Hydroxylation, Hydrogenation (low Pressure), Hydrolysis

• Kolbe-Schmitt, Ketalization

• Mannich, Micheal, Mitsunobu

• Nitration, Nitrosation

• Oxidation (Classical, TEMPO/NaOCl)

• Phosgenation

• Reduction, Reformatsky

• Sandmeyer, Saponification, Silylation, Sulfonation

• Thiophosgenation, Transesterification

• Ullmann

• Vilsmeier-Haack

• Williamson, Wittig