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Company Profile

Company Profile

Synthetech is a fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. Synthetech develops and manufactures amino acid derivatives, specialty amino acids, peptide fragments, and proprietary custom chiral intermediates primarily for the pharmaceutical and cosmeceutical industries.

Synthetech's products support the development and manufacture of therapeutic peptides and peptidomimetic small molecule drugs at every stage of a customer's clinical development pipeline; including regulatory starting materials advanced intermediates, and early-phase APIs. Synthetech's domestic and international customer base includes major pharmaceutical and emerging biopharmaceutical companies, as well as contract drug synthesis firms. Synthetech also supplies catalog quantities of specialty amino acids to research institutions, universities and drug discovery firms.

Synthetech expanded its core competency in 2006 to include a range of cross-linked and functionalized polymeric resins used widely in solid phase peptide synthesis (SPPS). This technology includes the procedure to attach the specified terminal amino acid to the resin, offering a key value-added service to peptide customers.

Our range of functionalized resins are used to produce peptide acids or peptide amides for combinatorial chemistry using an Fmoc or Boc synthetic method. They offer excellent batch-to-batch reproduction, and controlled, optimized particle sizes. These benefits promote improved product quality and increased yields. Resins are available from lab to commercial scale. Our resin portfolio will include Merrifield, Aminomethyl, MBHA, Wang, 2-CTC and a wide range of specialty resins.

 

Product Offering (Starting Materials, Intermediates, early-phase APIs)

• Peptide Fragments
• Custom Chiral Intermediates

• Protected Amino Acid Derivatives (BOC, CBZ, FMOC,...)
• SPPS Resins (Merrifield, Wang, Aminomethyl, MBHA, Preloaded resins,...)
• Amino Alcohols (Phenylalaninol, Cyclohexyl­alaninol, Phenylglycinol...)
• Non-Natural Amino Acids (Naphthylalanine, Pyridylalanine, Indanylglycine, Thienylalanine, Diphenylalanine, Diphenylalanine)
• Beta Amino Acids (ß-4-Fluorophenylalanine, ß-4-Chlorophenylalanine,…)
• Beta- Homo Amino Acids (ß-4-Homochlorphenylalanine,...)

 

 

Manufacturing

Synthetech operates over 55m³ (14K gallon) of capacity in glass-lined and stainless steel reactors ranging in size from 20 to 10,000 liters (5 to 2,500 gallon). The company is large enough to own and apply the appropriate technology and equipment to efficiently and cost-effectively complete a project, and small enough to be responsive and flexible in serving customers.

 

Safety & Quality

Synthetech is committed to the delivery of high-quality products and to the operation of a safe and environmentally responsible facility. Our quality program includes the commitment to manufacture within a cGMP environment and has been certified by numerous customer audits of our facilities. Synthetech safety and environmental programs have been recognized by outside organizations, including receipt of the SOCMA Responsible Care Achievement Award (2001-2005) and a certificate of recognition by Oregon OSHA under its Safety and Health Achievement Recognition Program (2003-2005